Migraine Pain Medication: My Failed List

Here is my long the list of the migraine pain medication that did not work for me and the side effects I experienced. I did trial some things on this list for 18 months or so, unless I had a severe reaction like Stemetil, Endep and Prothiaden.

So I feel I gave the drugs a fair amount of time to work back then.

I would not wait so long for results now. Wishful thinking got in my way. Sad but true.

It might even be called denial!

I am here to remind you to never lose hope – OK.

Persevere. Don't give up.

You will find something that works, or at least something that will help you manage the pain just a little better. Don't sabotage your chances at living a pain free life because of my results below. Luckily every body's body is different.

I kept going until I found something that worked and I am here to tell you that everything gets easier from there.

There is more hope now for effective treatment than ever before. Researchers are able to develop solutions much faster than ever before with today's technology. However, we are still waiting for a cure. Migraines teach us patience and tolerance on many levels – that’s for sure.

Here is what's available now for pain relief:

Over the Counter Migraine Pain Medication

Over the counter (OTC): Aspirin, Advil, Panadol (paracetamol), Tylenol, Mersyndol. None of these worked for me. Now I know why, do not take headache tablets for migraines.

Ibuprofen is preferable for migraines and remember migraines are not headaches. Read migraine vs headache for more details.

Prescription Migraine Pain Medication

Stemetil® (prochlorperazine) – this is commonly used as an anti-nausea tablet in low dose form but in higher doses it is also used for psychiatric illnesses. It works by blocking the dopamine receptors in the brain. I ended up in hospital on this one. Allergic reaction they told me.

So much for controlling my new psychotic condition caused by too many migraines – OK now I am joking. But I did feel like I was going crazy on many occasions.

Migraine Pain Medication

I have a confession. I am terrified of needles and drugs.

I fainted getting my ears pierced.

And I am afraid to take a migraine pain medication when I don't know what it will do to me.

Luckily, I have only woken up in hospital once.

So, it's taking me awhile to get around to having Botox.

The failed list continues:

Betaloc® – is a beta-adrenergic blocking agent.

Codeine® - is in a group of drugs called narcotic pain medicines. It is commonly used to treat mild to moderately severe pain and it is addictive. It did absolutely nothing for pain reduction on its own, so I stopped taking the ibuprofen with it to reduce constipation. My doctor, at the time, suggested I try it separately, and she was right.

Sandomigran® (pizotifen malate) - is a competitive serotonin antagonist, antihistamine and some other things I cannot pronounce. It is used as a prophylactic treatment only, not for the acute phase. This was the first drug I was given. I was told "it's just like aspirin", but it had no effect on the migraines. And so the journey for effective pain relief began.

Prothiaden® (dosulepin) - also called Dothiepin, Dothep, Thaden and Dopress. It is an antidepressant. Dosulepin is said to work by preventing serotonin and noradrenaline from being reabsorbed back into the nerve cells in your brain. Although it is supposed to help relieve depression – I developed suicidal thoughts and had very graphic and horrific nightmares. I lasted one week on this drug.

Inderal® (propranolol hydrochloride) - this is also known as Betaloc. I did not have a failed list back then, so it turned out that I tried the same drugs twice as they had different names in different countries. It is used to treat high blood pressure and as I have low blood pressure I got quite ill on this migraine pain medication.

Periactin® (cyproheptadine) – is an antihistamine. I never quite figured out why antihistamines had anything to do with migraines, but I took it anyway. I experienced suicidal thoughts on this migraine pain medication too, so I did not last long. I think I endured the nightmares for 6 weeks, as my doctor was tired of me giving up on all the drugs.

Sumatriptan (sumatriptan succinate) - also called Imitrex®, Imigran® – is a triptan and comes under the class of drugs called selective serotonin receptor agonists. It is used for migraines and cluster headaches. There were only oral tablets when I tried this, no nasal spray, but I felt like I was having a heart attack. I did feel great after wards though, no hangover effect afterwards like I often get. The chest pain really scared me, so I had to let go of the euphoric after effects.

Zolmitriptan - also called Zomig® - is a triptan and comes under the class of drugs called selective serotonin receptor agonists, this one targets “the 1B and 1D subtypes”. It is used for acute migraine treatment. It also felt too strong for me, in that the side effects were like a heart attack. And it took me about three days to recover.

Rizatriptan – also called Maxalt® – I recently (2011) tried these lovely peppermint wafers that dissolve on the tongue. I loved the idea of not having to eat food (at 4am) with the tablet. I loved that it felt like I did not take a tablet at all.

However, the abortive power did not last long enough and I had to take more than felt right. It was still within the limits, but I had to take it more often than the Naramig I was already on.

I did persevere for 3 migraines, doctor orders, but developed a vomiting cycle. The chemist (pharmacist) actually mentioned to return to the Naramig so as not to strengthen the new vomiting cycle into a habit for the body.

Herbal Pain Relief Failed Too ... Waaaah!

Feverfew (tanacetum parthenium) – is ”a member of the sunflower family, has been used for centuries in European folk medicine as a remedy for headaches, arthritis, and fevers”. Feverfew is widely used around the globe to treat migraine headaches.

I drank the tea and tried the capsules, but both times my tongue and chin swelled. I persevered for a month with no reduction in migraines and ignored the allergic reaction as long as I could. Alas, I could no longer try this natural remedy. So I returned to my reliable migraine pain medication once more. I've written more about feverfew here.

Butterbur – (petasites frigidus, petasites hybridus, or petasites japonicus)

Also called: blatterdock , bog rhubarb , bogshorns , butter-dock , butterfly dock , coltsfoot , exwort , fuki (in Japanese), pestilence-wort , pestwurz (in German), petadolex , petaforce , and tesalin.

Even though there have only been a few small clinical trials that have shown some benefit of treating migraines with butterbur, it is a widely used natural migraine pain medication.

Some adverse reactions are gastro intestinal symptoms and reduced testosterone production has been reported. I was not aware of any adverse reactions at the time, but I did have low hormone levels. There is also something else to be aware of with butterbur and I will quote:

”Pyrrolizidine alkaloids found in butterbur are known liver toxins with carcinogenic and mutagenic potential. Commercial dosage forms must be free of hepatotoxic pyrrolizidine alkaloids”.

I took these doses: 1 x 500 mgs (day one), 2 x 250 mgs (day two – split dose), and then 2 times per day x 75 mgs on a maintenance dose for 18 months. I did have a significant reduction in intensity and reduced occurrence looking back at my records. After 1 year my migraines reduced to 13 days per month, which was down from 22. I went another six months and stopped.

Tricyclic Antidepressant, Cox-Enzyme Inhibitors and an Anti-convulsant

Endep® – (amitriptyline) - also called Elavil, Vanatrip - is a tricyclic antidepressant that has also been used as a Migraine treatment for many years now. In fact it was one of the first medications recognized as a potential migraine prophylactic or preventive. I felt like my head was in a clear plastic bubble on this migraine pain medication.

It was like I could see everything, but I could not feel anything or connect to anyone. I persevered on this tablet too, for a bout 6 months until I got so depressed my doctor took me off it. I recall weaning off ever so slowly, and feeling better and better each day. This one was not for me.

Celebrex® (celecoxib) – is in a class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs). It is also widely used as a migraine pain medication. It is a “Cox-Enzyme Inhibitor” used to reduce pain, fever, inflammation, and stiffness caused by osteoarthritis and rheumatoid arthritis.

Vioxx® (rofecoxib) – was approved by the FDA on Apr 1, 2004 as the first and only COX-2 specific inhibitor migraine pain medication for acute treatment of migraine headache in adults. Are you bored yet? You might be, this has gotten really long. So here are some shorter versions.

Epilim® (sodium valproate) - is an anticonvulsant widely used for treating epilepsy. It was given to me as a preventive but after reading all the side effects and the fact that only Panadol can accompany it, which does nothing for my pain levels, and the weight gain turned me off totally. I did not need to add more problems to the mix.

Needless to say, the side effects sounded worse than just suffering with this pain that I was now familiar with and had a plan developed. My doctor prescribed 400 mgs per day for me, but I gave up once again. I was deflated.

What Did Work For Me?

Naramig. It was some months later – in 2003 - I found Naramig.

It was recommended by a shiatsu client of mine, at the time (not a doctor!). She was using it from back surgery and swore by it for pain relief.

And the rest is history. Using this migraine pain medication, I slowly got my life back.

More Failures - Vitamins, Minerals and Bio-Identical Hormones

I took B2 – 400 mgs per day until my skin turned orange. This took about 24 months.

I used Progesterone Cream for ten years. As some migraines are from dropped estrogen levels, the doctor highly recommend this instead of migraine pain medication. Initially the migraines reduced from 30 out of 40 days, to 22 out of 30 days.

After a number of years, migraines have remained at 20 days per month or so. My current doctor has taken me off, thankfully, as the results are just not good enough. I like this new doctor.

I had B2 and B Dose Forte injections in the bum for 18 months – ouch. It left bruising and lumps formed on my buttocks (too much?) with no change in my migraines. Emotionally I felt much better and I felt more energetic for 3 days after the injections. I guess I needed the vitamins.

I also tried: magnesium pump injections for 18 months with no reduction what so ever; 5HTP – nothing; and SAM-e which was very good for depression (I am still on it I like it so much) but there is no noticeable change in the current pattern of migraines.

I highly recommend trying SAM-e if you are feeling depressed, after checking with your doctor that is.

Thyroid Supplementation

I tried other things like natural thyroid extract. I noticed that the depression disappeared overnight (pre SAM-e) on 90mgs of thyroid extract but crashed after 1 week. I did experience a significant reduction in migraine frequency down to 7 days this month, down from the 13.

However this was too high a dose for my body to maintain and for over 3 weeks I could not get out of bed. It took almost 18 months to discover the correct dose and I ended up on 15 mgs with no effect on my migraines. I went back up to 22 per month.

I tried taking T3 – Oroxine – (synthetic) for three years. This is most commonly prescribed for hypothyroid condition, which I also now have. The migraines reduced to 11 days per month for a few months, but this was not maintained. Sadly.

I also tried taking T4 – Tertroxin – (synthetic) most commonly prescribed for REV T3, Wilson’s temperature syndrome. in combination with the T3 above. The migraines reduced in occurrence to 11 – 16 days out of a month. But again this was not maintained.

I am doing a REV T3 trial as we speak. I've done 2 months now, and am about to start another cycle. So - wish me luck!

Update - I did 5 trials, it took most of this year and my thyroid did not kick in to work. So now I am on the normal dose covered by Medicare.

Enduring Trial and Error

So you see, I have also had to endure trial and error when it comes to migraine pain medication. And I tell you all this in detail in the hope that it might help you persevere and find hope to find your best possible case scenario with these debilitating life altering migraines.

Whatever migraine pain medication you can find, alternative or synthetic that works for you is worth finding. Like I’ve said before migraines teach us patience, tolerance and compassion on so many levels. Mine have taught me to be prepared. I don't leave home without my Naramig in my purse.

Don't leave home without your meds!

To Save You From This Same Fate

I have a step by step pain management plan with a few different plans for you to take to your doctor and work through finding the right migraine pain medication.

You should be able to discover what works for you in a fraction of the time I did. Plus, if you haven't tried any of the triptans I suggest you consult with your doctor to see if it's an option for you.

Migraine Pain Medication References:
1. Butterbur (2009) [Online], Available at: http://www.drugs.com/npp/butterbur.html Accessed June 12, 2016 - updated 2018.
2. Better Health Victoria Government Australia (2015) Sandomigran [Online], available at: https://www.betterhealth.vic.gov.au/~/media/bhc/files/medicine%20guides%20import/05/cmi5824.pdf Accessed June 12, 2016.
3. Net Doctor (2014) Stemetil [Online], Available at: http://www.netdoctor.co.uk/cancer/medicines/stemetil.html Accessed June 12, 2016 - updated 2018.
4. Robert, T (2016) About.com Celebrex [Online], Available at: https://www.verywell.com/celebrex-as-a-migraine-treatment-and-why-its-unique-1719704  Accessed June 12, 2016.
5. University of Maryland Medical Center (2015) Feverfew [Online], Available at: http://www.umm.edu/altmed/articles/feverfew-000243.htm Accessed June 12, 2016.
6. Vioxx (2004) [Online], Available at: http://www.drugs.com/news/fda-approves-vioxx-acute-migraine-adults-3473.html Accessed June 12, 2016 - updated 2018.

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