Migraine Causes: A Medical Mystery

Underlying migraine causes are not fully understood by the medical profession. That's the bad news.

The good news is, it is generally believed that the causes may be related to a combination of genetic and environmental factors, and this implies that you are able (should be able) to control them to some degree.

Migraine Causes: A Medical Mystery

Approximately two-thirds of the people diagnosed are found to have a family history of the condition, and they were rarely contributed to a single gene defect, until recently.

Back in September 2010, Professor Lyn Griffith, director of Genomic Research Center and the Griffith Institute for Health here in Australia, at Queensland’s Griffith University, discovered the “TRESK” gene that directly causes a common type of migraine.

It took more than 15 years of research and she used over 3,000 individuals, which is a huge sample. YAY! That means it's reliable. 

More specifically it's called “rs1835740” aka the “TRESK” gene. It is now linked to what causes migraines. I tested negative ... so that's not my piece of the puzzle.

Migraines are associated with several psychological conditions such as anxiety, depression and bipolar disorder, as well as many biological triggers or events.

I was continuously told that I was depressed so I got migraines. Gosh that used to get my shirt in a knot! I say I only got / get depressed because I get migraines and dealing with a chronic illness is no piece of cake. Certainly not chocolate cake! 

More Genetic Migraine Facts

Studies of identical twins suggest there is about a 50 percent likelihood that a genetic influence contributed to the development of migraine headaches.

This genetic relationship appeared to be stronger in cases of migraines with aura, than in cases of migraines without aura.

Click here to read more about migraine aura.

The studies revealed several specific gene variants slightly increased the risk. Rarely will single gene disorders result in the development of migraines. I guess as in my case.

One such possibility is known as familial hemiplegic. This type is with aura; you only need to inherit the abnormal gene from one parent. The disorder is related to gene coding variations in proteins involved in transporting ions.

Another genetic disorder believed to cause migraines is cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), which also contributes to subcortical cerebral infarcts, mood disorders and progressive dementia.

Man, say that three times fast.

How to Pin Down What Causes Migraine

Migraine causes are so difficult to define, because the disorder is so complex.

Migraine causes are so difficult to define, because the disorder is so complex. It involves the brain, and the blood vessels surrounding the brain and running throughout the head.

Although the theories change over time.

Unlike other brain disorders, migraines can not be detected with a brain scan, therefore a diagnosis can only be made based on symptoms.

Under certain conditions the brain can become hyperactive. This hyperactivity sets off a series of chemical reactions that irritate the nerves, causing them to send out pain signals throughout the head.

This in turn causes the blood vessels to expand, which makes them release even more chemicals, further irritating the nerves.

Conditions believed to start this chemical reaction and contribute to the onset of a migraine attack include:

• alcoholic beverages, especially beer and red wine
• foods that are pickled, fermented or marinated
• aged cheeses
• MSG (monosodium glutamate)
• aspartame
• chocolate
• caffeine
• tobacco, or being around someone smoking tobacco
• some types of smoked fish
• chicken liver
• figs
• some types of beans
• foods with nitrates such as bacon, salami and wieners
• peanut butter and other nuts
• avocados
• bananas
• citrus fruits
• onions
• certain dairy products

Other Migraine Causes

Other conditions believed to trigger a migraine headache include:

Migraines can be quite a maze.

• environmental triggers such as light, noise or smell

• not eating properly, or fasting

• stress, either emotional or physical including depression

• not sleeping well, or a change in sleeping habits

• sudden changes in the weather

• hormones, especially during menstrual cycle fluctuations, or the onset of menopause

• birth control pills

Other migraine triggers are believed to be related to serotonin levels. Serotonin is the chemical in the brain that regulates pain in the nervous system.

Studies show that the level of serotonin drops during a migraine attack. This drop could cause the trigeminal nerve system, which is a major pathway for pain, to release a substance called neuropeptide. The neuropeptides travel to the outer covering of the brain, resulting in a severe headache.

Serotonin levels also affect blood sugar levels which is why food, or lack of food is believed to often be the cause of a migraine attack.

I hope this helps explain why migraine causes are different to triggers.

Women usually experience worse migraines around puberty, and after menopause the migraines usually disappear. This leads many experts to believe hormones are the main migraine causes, and why women develop the condition more often than men.

For more details, please read the post Menopause Headaches: When Will They Stop?

Ways to Prevent Migraine

These are all simple ways to help prevent an attack when you feel it coming on.

• Read How To Prevent Migraines.

• Use ice packs for migraine relief, because they work best for fast action ... and trust me, you will need fast relief.

Biofeedback for migraine reduction can help you train your body to avoid your next attack.

Being proactive will serve you well long term.

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