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My #1 Choice - Magnesium Breakthrough - combines 7 types of magnesium in a humic/fulvic monoatomic blend to optimize absorption. I personally use it to combat attacks – nothing else compares.


Are Digestion Problems Causing Your Migraine Attacks?

Written and verified by Holly Hazen

Are digestion problems triggering migraine headaches for you? They sure could be. Talk about the microbiome is everywhere now. This is now a widely accepted problem that is connected to migraines. You may have heard of leaky gut, irritable bowel syndrome (IBS), or other GI disorders. 

Let's start with the basics of digestion first and why it might be linked to your migraine attacks.

Digestion Problems in Migraine @migrainesavvyLearn about your digestive process to help you determine if it might be contributing to your attacks.

First, let me tell you a little bit about what I have discovered on this part of the migraine journey.

I started taking digestive enzymes a few years ago.

I recently started taking a double and then triple dose of digestive enzymes and additional Betaine HCL and Pepsin.

My migraines reduced in frequency.

This was good news for me.

I was under the instructions of my nutrition doctor, so please don't just start taking lots of supplements at home without professional advice and monitoring. Taking enzymes to aid digestion is common now a days, but this is just one thing to try for digestion problems.

I am going to give you a lot of details below, because there are so many products on the market, its important to get the one that you need. I always urge you to seek professional advice first, so your health care provider can take everything into consideration.

I don't take anything else... I LOVE these enzymes!

My #1. MassZymes by BiOptimizers – click this link to save 10% with my code. These enzymes are by far the best product I have found so far in terms of getting results.

What Does Your Digestion Have To Do With Your Migraine?

A migraine attack causes gastroparesis, also known as delayed gastric emptying. It slows down the digestive process to take care of the attack.

This is why different medication(s) you take to abort the attack may not work very well. 

Poor digestion or digestion problems, according to the Nutritional Almanac (1998), is one of the causes of migraine headache.

They also list: "diseases of the eye, nose, or throat, trauma to the head, air pollution, drugs, alcohol, tobacco, fever, generalized body infections, disturbances of the digestive tract, and circulatory system, brain disorders, incorrect eyewear or eye strain, anemia, low blood sugar, niacin or pantothenic acid deficiency, and overdose of vitamin A, mould allergy, allergies, salt, excessive carbohydrates, allergenic foods (from MSG, wheat, citric acid, marinated foods, and fermented foods), oral contraceptives or other sources of estrogen's, constipation or bowel problems, grinding teeth (bruxism), improper bite, the chewing of gum, food additives such as nitrites in meats, aspartame, stuffy rooms (caused by an electrical imbalance of the ion count of the air), and premenstruation (possibly a result of water retention in the brain tissues, which can be relieved by vitamin B6)."

This list seems to include several triggers of migraine headache. The heading is headache and not migraine, so I always make that distinction between the two. As you already know, they are not the same to me. Anyway – back to digestion problems.

"The body uses protein to convert food into the storage forms of energy. The type of food consumed determines the quantity and quality of that energy" and as Dr. Gillian McKeith says "you are what you eat."

I say - we are what we digest and then absorb!

"Carbohydrates, both simple and complex, are the chief food source and are essential to the body" and protein is needed to convert food to energy and it is used to fill in when other supplies of energy are required. We need to eat nuts and seeds, grains, etc and they are all digested at different rates.

Many people believe in food combining, especially if you have digestion problems. It has great success rates in reducing discomfort. I try to follow it by eating fruit away from other meals. But with all the migraine foods I avoid, I prefer to believe that I just need to eat everything else in moderation. Unless it causes obvious digestion problems for me like the ones listed below.

The Basics of Digestion

Digestion is a very complex area, so I will just keep it all as simply as I can.

Digestion actually begins in the mouth.

There are 2 digestive system function processes that take place in our body - mechanical digestion and chemical digestion. The mouth is where the mechanical digestion process starts.

Your saliva in your mouth provides ptyalin to soften the food and enzymes to break down the food as the teeth grind or ‘masticate’ the food. So the teeth break the food down into small pieces and this enables the chemicals required to start digestion. The tongue muscle then helps to form a ball and squeeze it down the throat.

So the ball of food goes down the esophagus and into the stomach – this is still part of the mechanical process. The stomach is where the food is broken down further with chemicals and enzymes enabling a separation between nutrients to be taken into the body and waste products to be eliminated.

Our digestion plays such an important role for our body’s well being. The nutrients that get to the blood in our body are directly determined by what we put in our mouths. Nutrient deficiency is already known to be high in people living with migraine.

What our digestive system looks like inside @migrainesavvyWhat our digestive system looks like inside @migrainesavvy

Chew Your Food Well

Always chew your food, even if it is soup or stew.

I have introduced a new idea of blending your food into a puree for a day or so after a long migraine in my migraine diet article. This replaces the mechanical digestion process which takes place by chewing. Its like being pre-chewed! However, you still need to chew our pureed food to start the chemical digestive process and allow the digestive enzymes in your saliva to mix with your food.

Chewing activates the necessary enzymes to begin breaking down the food in your mouth. By mimicking the natural process of chewing, your food will digest much more easily resulting in better assimilation all of the vitamins and nutrients.

F O O D = F U E L

By feeding yourself food that your body can utilize easily, you consequently give it optimum nutrition to recover faster and help out those digestion problems at the same time.

Digestion Problems Look Like...

Ask yourself – how many of these digestion problems do I experience and hopefully this part of the page will answer if this might be one of your migraine triggers.

Common digestion problems are: bloating, constipation, diarrhea, gas, Irritable Bowel Syndrome, stomach pains and cramps.

I will not discuss other digestive disorders like: heartburn (GERD), hemorrhoids, lactose intolerance, and ulcers but I thought they were digestion problems worth mentioning too.


Digestion problems cause constipation. It is one of the most common symptoms that accompany migraines. Chronic constipation can become one of the causes of migraine headache. Many painkillers contain codeine phosphate or other chemicals that cause constipation.

It is a bit of a vicious cycle for us migraineurs who depend on codeine to reduce our pain.

The actual definition of constipation is when bowel movements are "less than 3 times per week". I’ve said before that staying hydrated is an important issue for us migraineurs, and now you know why. Most of us will struggle with this one.

Digestion problems can also cause diarrhea. Evacuating your bowels more than 3 times a day, in a watery form of diarrhea can lead to dehydration which can be a very dangerous condition. It is not considered one of the causes of migraine headache. But dehydration is, so please be aware.

Flatulence (Intestinal Gas)

Gas is another common digestive disturbance. Most people experience gas but if you have pain that accompanies it, it may mean something else is happening. I wish I could do a survey and see how many migraineurs have gas, and if they associate it as one of their causes of migraine headache.

Gas can be caused by swallowing too much air when you eat or eating too much. Eating too much can overwhelm the digestive enzymes and the undigested food becomes putrefied which forms bacteria and then results as smelly gas.

"Effective digestion depends upon hydrochloric acid, bile, and other digestive secretions and enzymes"(Nutrition Almanac, 1998, p.226).

For example, in order to utilize your own secretions in say fruit juice, you should hold it in your mouth and swirl it around for a little bit (pretend to chew) before swallowing it. This assists the digestion process.

My nutrition doctor recommends taking 2 digestive enzymes after every meal now for digestion problems, as all of my food is cooked and 2 meals are pureed. Having gas, even if it's extremely painful, is not considered to be one of the causes of migraine headache.

Raw food can cause problems with parasites, which is another thing to consider. Read about that on Causes of Migraine Headache: Parasites.

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Digestion plays such an important role for our body’s well being @migrainesavvy #migraines #migrainerelief #headaches

Do Digestive Enzymes Help?

Using digestive enzymes supports poor digestion. Incomplete digestion, be it from too little Hydrochloric acid (HCL) in your stomach or other problems, can cause many problems like peptic ulcers as I mentioned above.

With centuries of cooking our food and with aging depleting our natural enzymes, it is possible to suffer from the improper digestion of our food, especially proteins and fats.

Low stomach acid disrupts the whole system. Consequences are poor mineral absorption, poor B12 absorption, and calcium remains insoluble and cannot be ionized – where it changes chemically to combine with other elements.

How you can tell – is to check your stools. Yup, I know, it sounds gross. But how else can you tell if you have undigested food. Just check what comes out and that will give you your answer.

I can only recommend this brand, even the prescribed enzymes like Creon did nothing for me and this migraine stomach! Just click on the image below for more details.

What Ingredients To Look For

My doctor had me on Eagle brand Digestaid which is made in Australia. It's quite hard to get a hold of and all practitioner products here in Australia must have a script from a doctor, naturopath or professional nutritionist first. I have an easier solution in this post.

But it's the ingredients that are important:

Active ingredients:

  • Betaine hydrochloride - 300mg
  • Pancreatin - 200mg
  • Pepsin - 100mg
  • Sodium tauroglycocholate - 50mg
  • Papain - 30mg
  • Bromelains - 20mg
  • Gentiana lutea - 20mg
  • Foeniculum vulgare powder - 2mg
  • Maltase 700 - 80mg
  • Potassium chloride - 25mg
  • Chromium amino acid chelate - 10mg
  • Peppermint oil - 1mg


Adults: Take 1 tablet, 3 times daily after food.


Vegan/Vegetarians – Please note that these digestive enzymes are bovine sourced. If you have stomach or duodenal ulcers, Digestaid can be quite stimulating, so please consider a course of Slippery Elm and Matrix Support with Cyto-bifidus prior to using Digestaid.

More Specifically - What Numbers To Look For

Without the HCL – and more enzyme like - Jon Barron so kindly tells us what to look for:

  • Protease: A minimum of 33,000 HUT should be adequate for most meals. (Remember, you can change your dose and take a second or third capsule when you eat a meal that requires it.)
  • Acid stable protease: 1,000 SAPU is most beneficial. You may find that many formulas have none of this at all, so you may have to search.
  • Lipase: 5,000 LU is adequate
  • Amylase: Look for 12,000 SKB
  • Lactase: 1,500 LACU 2,500 is best
  • Look for a variety of other enzymes such as: Malt diastase, Invertase, Glucoamylase, Cellulase, and Hemicellulase. You can also look for Alpha galactosidase if you experience problems with gas.

My #1 Choice in Enzymes

Now that you have all those numbers, this product just performs on another level all together. I LOVE IT!

MassZymes has a powerful nutrient called astrazyme™ - and paired with the industry’s strongest protein-digesting enzyme formula, it takes your muscle-building process up to the next level!

AstraZyme™ is a proprietary all-natural, plant-derived compound extracted from Panax ginseng and Astragalus using a proprietary processing technology.

It has been proven in 12 invitro studies to significantly enhance the absorption of many important nutrients - up to 66% more in certain cases - including key amino acids such as arginine, citrulline, and tryptophan... vitamins, such as folate... joint-protecting nutrients like glucosamine... and many more.

AstraZyme™ works by up-regulating protein transport on a DNA level, meaning it helps increase the amount of amino acids, glucose, vitamins, and other nutrients entering your intestinal cells.

MassZymes is the most effective protein-digesting enzyme I have used. I highly recommend it. 

You can read more about it here - MassZymes Details.

Here's the link to the shop - MassZymes Shop. Use my code SAV10 to get a 10% discount.

**Update! I just did a test after being on MassZymes for approximately 8-9 months. I've taken a week off, and what a difference! I am shocked. I am not sleeping as well; I am not full of energy, nor do I have that feeling of strength in my muscles I seemed to have a week ago; I am not digesting my food (lost my appetite actually) AND... I've had a few headaches bordering on migraine that I've not had all year. Oh - and I am hot flushing all day again.

So... I'm sold on this brand of digestive enzymes. And wishing I had found them sooner on this migraine and health journey. 5 years later, still on them. 

I hope you found this information useful to help determine if you feel poor digestion is a migraine trigger for you. There's more on food and diet in my course, it's free to enroll or you can get my 8-week food and supplement journal - in the bookstore now.

MIGRAINE CAUSES  Related Articles

How to be more migraine savvy right now...

Digestion Problems References:
1. Barron, Jon (2009) Digestive Enzymes - Raw Food Newsletter. [Online], Available at: Accessed Feb. 24, 2012. Material originally published at Copyright © 1999-2021. Baseline of Health® Foundation. Used by permission of the Baseline of Health® Foundation. All rights reserved worldwide.
2. Barron, Jon (2003) Choosing Your Digestive Enzymes Newsletter. [Online], Available at: Accessed Feb. 24, 2012. Updated Mar. 6, 2023
3. Kirschmann, G.J. and Kirschmann J.D. (1998) Nutrition Almanac (4th ed.) McGraw-Hill International Editions: Sydney. pp.224 - 238.
4. Pitchford, P. (2002) Healing with Whole Foods (3rd ed.). North Atlantic Books: Berkeley, CA. pp. 572 and 643.