Are Balanced Hormones A Cure For Migraine Headache? Hype Or Hope?

Can balancing your hormones stop migraines? Is this your cure for migraine headache? Many of my doctors have said "yes" and proceeded to balance my estrogen dominance with progesterone cream and DHEA supplements. FYI, it's not just one hormone we need to balance.

Let me tell you, after years of experimenting, where the hype is and where you can have hope.

Cure for Migraine Headache

Fluctuations in estrogen levels are believed to be one of the most common triggers of migraine headaches in women.

For many of us ladies, a condition called menstrual migraine plagues us each month. The treatment is the same as other migraines: non-steroidal anti-inflammatories (NSAID) like Naproxen, the long acting triptans Frova® and Amerge®, sedatives and even magnesium supplements. (Rothner MD, 2011)

Dr. Rothner, Director of the Pediatric/Adolescent Headache Clinic and Chairman Emeritus of Child Neurology at the Cleveland Clinic Foundation says that "Migraines that fall around menses are often more severe than those that strike at other times of the month." And here's the good news:

"Because these headaches are predictable, they can be planned for with acute or preventive treatments."

"Maintaining a healthy lifestyle, adequate hydration, and regular meal and sleep times can help you reduce susceptibility to migraine triggers.”

And balancing your hormones if you want to take an alternative approach.

You Know These Ones

You have most likely heard of estrogen and progesterone, but have you heard of pregnenolone and DHEA? Did you know that women need testosterone too? 

The roles that estrogen and progesterone play in migraine are critical and complex. 

Most practitioners will help you balance both of these together because the balance between them is just as important as their individual levels.

It is crucial to get both sides of the equation right for eliminating migraine, and all of the other additional symptoms us women experience during perimenopause and menopause.

I think my migraines are hormonal although no specialist has seen that pattern. I get them the week before, during and after and then have one week off. Thank God for that week off.

Using Bio-Identical hormones in the hope of a cure for migraine headache, if your migraines happen around your menstrual cycle may just prove to be a solution. So there is hope.

But keep reading to see where I think the hype is. And always remember it's all an experiment, there is currently no cure for migraine headache. But anything you can do to reduce them in any way (frequency of occurrence or intensity) is a victory.

Using Bio-identical Hormones As A Cure For Migraine Headache

According to Dr. Christiane Northrup it is essential to balance our hormones - specifically estrogen and progesterone. She says that normalizing hormones and neurotransmitters will normalize the excitation in the brain which should reduce or stop migraines

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She recommends 2% natural progesterone cream to her patients to relieve premenstrual or menopausal migraines.

Her dosage instructions are to use: one quarter to one half teaspoon of 2% progesterone cream on your soft skin areas (under arms and inner thighs I was told) 3 – 4 days before your period is due.

For a more acute treatment to prevent an oncoming migraine, you can apply one quarter teaspoon every 15 minutes. This is known to “calm neurons by acting on the GABA receptors in the brain, much like Valium.”

I found using progesterone cream very useful as one of my migraine headache remedies. It calmed me down, but after 4 – 6 hours of migraine symptoms, I was reluctant to continue with applying the cream every 15 minutes. And I found that the migraine would still strike eventually regardless of how much progesterone cream I used.

I did not want to overdose. I also experimented with 6% cream for many years, but as I was still getting twenty migraine days each month, she suggested I stop everything and start again from scratch.

Plus our hormones change a lot in ten years.

If you are going to experiment with balancing your hormones as a cure for migraine headache and you prefer the bio-identical hormone route, I would suggest finding a doctor to help you along the path and to recheck your hormone levels every two years or so.

Hype - No Cure For Migraine Headache

There are numerous products that advertise similar effectiveness to progesterone cream, and can be bought over the counter in many countries but I have found them useless against the strength of my migraine attacks.

Make sure you find a reputable product that your doctor approves of, or stick to their prescription. I trust my local pharmacist who has a great reputation and prescribed compounding services.

I tried Triest (tri estrogen) cream prepared by a local compounding pharmacy that contains all three estrogen's: 10% estradiol, 10% estrone and 80% estriol. It came in a tub with a syringe attached on top making it easy to measure the small dose I needed. 

There is a lot of controversy in this area. I decided to avoid using Premarin as an estrogen supplement (made from pregnant horse urine). From my research, it is more apt to cause headaches than bioidentical formulations or patches.

Avoid synthetic progestins that cause your blood vessels to constrict.

Also avoiding any synthetic progestin that causes constriction of the blood vessels is important too. The brand names to avoid are: Provera, Prempro, and the combination patches like Ortho Prefest and Activella, just to name a few. I would consider this hype but always check with your doctor first.

Let me tell you about DHEA before we get to the estrogen's as part of your cure for migraine headache. 


Dehydroepiandrosterone (DHEA) is a hormone produced by the adrenal glands.

It is a precursor for the estrogens and testosterone production in your body. 

Blood levels of DHEA are at their peak during your twenties and then decline as you age. By the age of 70 or 80 they will have decreased significantly to 20-30% of your peak levels.

My DHEA was very low and my doctor monitored it for years, while we played with doses from 5 to 25 mgs. Less was better for me.

Dr. Sergey Dzugan, author of The Migraine Cure, says we must “balance steroid hormones such as pregnenolone, DHEA, estrogen, progesterone, and testosterone; reset the function of the pineal gland using the hormone melatonin and other natural substances; restore gastrointestinal and digestive health using probiotics; and achieve a balance between calcium and magnesium, two minerals that play a crucial role in migraine.” (Dzugan, 2006).

Low levels of DHEA are also linked with a number of health problems including migraine, chronic inflammation, and depression, just to name a few. (ibid.)

Dr. Dzugan says that maintaining an optimal DHEA-to-cortisol ratio is important for achieving hormonal balance and eliminating migraine.

So you can see, the more I write the more I would have to write about the other hormones involved. Hormones are a complicated field. I suggest that you find a specialist if you suspect your migraines are hormone related.

Your general physician can check your DHEA levels, or more specifically DHEA-sulfate (DHEA-S) with a simple blood test. 

The range of DHEA in women is: standard reference range is 65-380 µg/dL and the optimal range is 350-430 µg/dL. Dr. Dzugan’s numbers suggest restoring the levels back to the peak range. For men, the optimal range is 500-640 ug/dL; for women, 250-380 ug/dL. The usual daily dose he suggests is 50-100 mg taken as an oral supplement. (ibid.)

In my attempt to get my DHEA levels up to the optimum, I discovered that I could not take the higher dose, it caused anxiety and panic attacks so I had to be happy with a lower reading.

Dr. Dzugan’s treatment gets a bit more complicated by recommending 7-keto DHEA supplementation in addition to regular DHEA, but it is not allowed here in Australia so I can’t comment on the results with that.

DHEA is not publicized as a cure for migraine headache. 

The Three Amigos – Estrone, Estradiol And Estriol

Estrogen is a blanket term used for several types of the hormones. There are three main types of estrogen in the human body: estrone, estradiol, and estriol. Men also have these hormones but they are found in lower levels.

Hormones effect every cell in our body and influence our organs. They are chemical messengers that carry instructions to cells throughout the body.

When our estrogens are balanced they work together to support the central nervous system, determine our female physical characteristics, and minimize loss of calcium from our bones. But wait, there’s more, they enhance our skin health, promote blood clotting, sexual function and support ovulation and reproduction. 

Hormones regulate our metabolism and the way our bodies use food. They even effect our reaction to emergencies and balance our moods.

You can see that the estrogens play critical roles in our bodies but they also have some risks as well. For example, estradiol and estrone are produced at lower levels naturally by the body as they have cancer causing abilities.

The body naturally makes more of estriol that is believed to have cancer reducing properties. When they are all in balance everything in the body functions better. Hence the cure for migraine headache. 

The form of bio-identical estrogen that I trialed was called Triest cream.

The compounded formulation normally consists of 90% estriol, 7% estradiol, and 3% estrone. But a compounding pharmacy will prepare this formulation based on your doctor’s prescription for you.

Cure for Migraine Headache

I applied the cream (there are gels now that are more efficient at absorption) every morning after my shower.

It is best to alternate between the soft skin areas:


inner forearm,

inner thighs or lower abdomen.

I wish I could say that all this experimenting and all this money was my cure for migraine headache, but it was not. 

The Link Between Estrogen And Migraine

My migraines seem to hit when my estrogen goes up or down. Movement seems to trigger my migraines. This is different for everyone. Some women will only have a migraine before their period.

I have written more in these posts: menstrual headaches and premenstrual headaches

Here is what Dr. Dzugan says about estrogen and migraine:

• The occurrence of migraine increases when a female's menstrual cycle first begins.

• Just before menstruation the decline in estrogen levels triggers a migraine episode in many women.

• It is common to see migraines decline during the second and third trimesters of pregnancy, when estrogen levels are high.

• After a woman gives birth the dramatic decline in estrogen levels can trigger a migraine attack. 

Getting the balance between estrogen and progesterone right is critical in the elimination of migraine. 

Hope - Could Progesterone Be Your Cure For Migraine Headache?

Progesterone levels also naturally rise and fall during a woman's monthly menstrual cycle. 

Perimenopause, missing ovulation and menopause causes progesterone fluctuations. Oh dear, it sounds like we are doomed as women!

Missing ovulation in any phase means that our body is producing lower levels of progesterone that contributes to imbalanced estrogens.

Dr. Dzugan says “This imbalance explains why many women begin to experience symptoms of perimenopause in their mid to late thirties and forties, and also why the peak incidence of migraine for women is between the ages of 35 and 45.” 

Now there is a huge controversy around bio-identical progesterone that chemically matches the natural hormone produced in our bodies and the synthetic progesterone-like substances called progestogens or progestins. 

Say that three times fast!

And then there is yam cream you can buy over the counter. Hype! 

Clients of mine, and friends have had no results with this, helping me to choose prescribed bio-identical hormone cream. 

I saw progesterone cream as a cure for migraine headache, and although it helped me feel a lot calmer, it did not affect the frequency, severity or duration of my attacks. Sadly NOT A CURE!

Dr. Dzugan recommends using “micronized progesterone USP. Micronized progesterone is also available as a gel (transdermal form), which is the form I recommend for migraine as well as for other conditions that benefit from hormone balancing.”

He also suggests an over-the-counter micronized cream product called ProFem as another alternative.

If you choose to experiment with balancing your hormones as a cure for migraine headache, then this is not something I would do without professional guidance from your doctor.

Or Testosterone? It's Not Just For Men

I also tried testosterone cream for many years. I found it gave me strength which I absolutely loved.

You might think this is just a male hormone but testosterone also helps with: mood, your energy levels, bone marrow production, fertility, and supports a healthy libido. 

Us ladies need testosterone, just not as much as men. As a cure for migraine headache, our testosterone levels need to be in balance to eliminate migraine.

“Measurement of testosterone levels is part of the male and female hormone panels that are used to identify the levels of other steroid hormones. The optimal range for men is 650-827 ng/dL; for women, 60-76 ng/dL.” (ibid).

There are many forms of testosterone available: oral supplements, injections, cream, gel and transdermal patch. 

A word of caution ladies. The body can convert DHEA to testosterone when it’s needed. So if you are also restoring your DHEA levels using supplementation already, get your doctor to help you monitor all of that.

Making changes in your diet can effect hormones, so you really do need to find a good doctor to help you with all of this.

This has been a general overview, but you can see that there are more hormones to balance than just our estrogens. What hormone balancing measures have you tried and found your cure for migraine headache? Let us know in the Facebook comments box below.

What I Use Now

I don't use any bio-identical hormones now, and I have been off them all for about six years. I am sad to say that I will be trialing them again with my new doctor as she believes us women need to stay balanced regardless of the migraines.

I can say that just because this was not my cure for migraine headache it does not mean that you won't get some desirable results. It's all trial and error.

Meditating and doing gentle exercise like yoga and tai chi remain in my routine to manage my migraines and overall health.

I still have professional pain counseling for a little extra migraine support each month. I think it is crucial to have someone to talk to that I can be real with.

I know you know what I mean.

Along with ice packs and biofeedback, I use these CD's above regularly when I lay down to relax. Give one a try.

Want More on HRT?

The largest study ever done on hormone replacement is called the Women’s Health Initiative Hormone Therapy Study. Click on National Institutes of Health if you are considering menopausal hormone therapy and find out about the potential risks and benefits.

Cure for Migraine Headache References:

1. Northrup, C. M.D. (2012) Migraines [Available Online], Available at: Accessed on Feb 2, 2016.

2. Dzugan, Sergey A. MD, PhD (2006) The Migraine Cure. Cited at

3. David Rothner MD. (2001) Breaking The Cycle. [Online], Available at: Volume 4 issue 3 pg 22. Accessed Feb. 01, 2016.

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With this new information, what one thing can you do now to reduce your attacks?